| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
Peptide derived from Hu A4GALT/CD77. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
产品描述 ： |
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. |
| 适用物种 ： |
Hu, Mo, Rat, Chi, Dog, Pig, |
| 应用说明 ： |
E: 1:500-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
4 N acetylglucosaminyltransferase; 4-galactosyltransferase; A14GALT; A4GALT; A4GALT1; A4GAT_Hu; Alpha 1 4 galactosyltransferase;Alpha-1; Alpha4Gal T1; CD 77; CD77 synthase; GB3 synthase; Gb3S; Globotriaosylceramide synthase; Lactosylceramide 4 alpha galactosyltransferase; P blood group (P one antigen); P(k) antigen synthase; P1; P1/Pk synthase; PK; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
|
产品说明 ： |
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