| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
peptide corresponding to a sequence at the N-terminus of human KMT2A. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
产品描述 ： |
MLL(Myeloid/lymphoid or mixed Lineage Leukemia gene),also called MLL1, ALL1 or CXX7, is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia(AML), acute lymphoblastic leukemia(ALL), or mixed lineage(biphenotypic) leukemia(MLL). The MLL gene encodes a DNA-binding protein that methylates histone H3 lys4(H3K4) and positively regulates expression of target genes, including multiple HOX genes. The MLL gene is mapped on 11q23.3. A leukemogenicMLL fusion protein that activates HOX expression had no effect on histone methylation, suggesting a distinct mechanism for gene regulation by MLLand MLL fusion proteins. The MLL gene encodes a large nuclear protein that is required for the maintenance of HOX gene expression. MLL is cleaved at 2 conserved sites to generate an N-terminal 320-kD fragment(N320) and a C-terminal 180-kD fragment(C180), which heterodimerize to stabilize the complex and confer its subnuclear destination. |
| 适用物种 ： |
Hu, Mo |
| 应用说明 ： |
WB: 1:200-1:1000 |
| 别 名 ： |
Acute lymphocytic leukemia 1 antibody;ALL1 antibody;C-terminal cleavage product of 180 kDa antibody;CXXC-type zinc finger protein 7 antibody;CXXC7 antibody;HRX antibody;HTRX1 antibody. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
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产品说明 ： |
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