RAB5A Antibody_华拓生物

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RAB5A Antibody

产品名称 ： RAB5A Antibody

中文名称 ： ras癌基因家族Rab5蛋白抗体

产品类别 ：一抗

品　　牌 ： PLLABS

货　　号 ： PL0402414

规　　格 ： 0.1mg(1mg/ml)

详细信息

克隆类型：	Rabbit Polyclonal IgG
免疫原：	peptide corresponding to a sequence in the middle region of human Rab5.
纯化方式：	Immunogen affinity purified
缓冲液：	PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
产品描述：	RAB5A(Ras-associated protein RAB5A), also called RAB5, is a protein that in humans is encoded by the RAB5A gene. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. The RAB5A gene is mapped on 3p24.3. Tuberin functions as a RAB5GAP in vivo to negatively regulate RAB5-GTP activity in endocytosis. Ectopically expressed ALS2 localized with RAB5 and early endosome antigen-1 onto early endosomal compartments and stimulated the enlargement of endosomes in cultured cortical neurons. RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling. RAB5 signals to the actin cytoskeleton through RNTRE, a RAB5-specific GTPase-activating protein(GAP). RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes. RAB5 activation was either continuous or repetitive for up to 10 minutes, but it ended before the collapse of engulfed apoptotic cells.
适用物种：	Hu, Mo, Rat
应用说明：	WB: 1:200-1:1000 IHC: 1:500-1:1000
别　　名：	Ras-related protein Rab-5A;RAB5A;RAB5.
保存条件：	Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted.
标记物：	PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体
产品说明：

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