| 克隆类型 ： |
Rabbit Polyclonal IgG |
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免 疫 原 ： |
peptide corresponding to a sequence in the middle region of mouse Aurora A. |
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纯化方式 ： |
Immunogen affinity purified |
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缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
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产品描述 ： |
AURKA(aurora kinase A), also called ARK1, AurA, AIK , AURORA2 ,BTAK, PPP1R47, STK7, STK15,STK6, is a mitotic centrosomal protein kinase. The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis. Aurora A is a member of a family of mitotic serine/threonine kinases. Cell cycle and Northern blot analyses showed that peak expression of AURKA occurs during the G2/M phase and then decreases. By fluorescence in situ hybridization, AURKA gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression of Aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry. |
| 适用物种 ： |
Mo, Rat |
| 应用说明 ： |
WB: 1:200-1:1000 |
| 别 名 ： |
Aurora kinase A;2.7.11.1;Aurora 2;Aurora family kinase 1;Aurora/IPL1-related kinase 1;ARK-1;Aurora-related kinase 1;Ipl1- and aurora-related kinase 1;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase Ayk1;Serine/threonine-protein kinase aurora-A;Aurka;Aik, Airk, Ark1, Aura, Ayk1, Btak, Iak1, Stk15, Stk6. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
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产品说明 ： |
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