MBD4 Antibody_华拓生物

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MBD4 Antibody

产品名称 ： MBD4 Antibody

中文名称 ：甲基化CpG结合蛋白MBD4抗体

产品类别 ：一抗

品　　牌 ： PLLABS

货　　号 ： PL0402686

规　　格 ： 0.1mg(1mg/ml)

详细信息

克隆类型：	Rabbit Polyclonal IgG
免疫原：	peptide corresponding to a sequence at the C-terminus of human MBD4.
纯化方式：	Immunogen affinity purified
缓冲液：	PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
产品描述：	MBD4(Methyl-CpG-Binding Domain Protein 4), also known as MED1, is a protein that in humans is encoded by the MBD4 gene. MBD4 specifically binds methylated DNA, colocalizes with methylated sequences, and is likely to mediate the effects of DNA methylation in mammalian cells(Hendrich and Bird, 1998). Riccio et al.(1999) mapped the MBD4 gene to chromosome 3q21-q22 by FISH. Hendrich and Bird(1998) found that both MBD2 and MBD4 specifically bound methylated DNA in vitro and colocalized with methylated sequences in vivo. They concluded that MBD2 and MBD4 are likely to be mediators of the effects of DNA methylation in mammalian cells. Hendrich et al.(1999) showed that MBD4 contains a methyl-CpG-binding domain that can efficiently remove thymine or uracil from mismatched CpG sites in vitro.
适用物种：	Hu, Mo, Rat
应用说明：	WB: 1:200-1:1000
别　　名：	Methyl-CpG-binding domain protein 4;3.2.2.-;Methyl-CpG-binding endonuclease 1;Methyl-CpG-binding protein MBD4;Mismatch-specific DNA N-glycosylase;MBD4;MED1.
保存条件：	Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted.
标记物：	PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体
产品说明：

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