| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse IRS-4. |
|
产品描述 ： |
The family of insulin receptor substrates (IRS) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions although the distinct physiological roles of each IRS are unclear. IRS-4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS-4 interacts with cytoplasmic signaling molecules that contain SH2 domains such as IGF1R and FGFR1. IRS-4 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS-4 is involved in the proliferation and differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. |
| 适用物种 ： |
M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 别 名 ： |
Insulin receptor substrate 4; IRS-4; 160 kDa phosphotyrosine protein; PY160; IRS4 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/irs-4-antibody |
| 标 记 物 ： |
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产品说明 ： |
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