| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PTP-1B. |
|
产品描述 ： |
Protein-tyrosine phosphatase 1B (PTP-1B), a member of the protein tyrosine phosphatase (PTP) catalyzes the hydrolysis of the phosphate monoesters specifically in tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentation, mitotic cycle, and oncogenic transformation. PTP-1B acts as a negative regulator of insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor kinase. PTP-1B dephosphorylates epidermal growth factor kinase as well as JAK2 and TYK2 kinases in cell growth control and cell response to interferon stimulation. PTP-1B plays an important role in CKII- and p60c-src-induced signal tranduction cascades. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 别 名 ： |
PTP-1B; Protein-tyrosine phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTPN1; PTP1B |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/ptp-1b-antibody |
| 标 记 物 ： |
|
|
产品说明 ： |
|
