| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse WNK4. |
|
产品描述 ： |
Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is exclusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII). |
| 适用物种 ： |
M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
WNK4; Ser/Thr-protein kinase WNK4; Serine/threonine-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine–deficient 4 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
产品文献 ： |
Singh AK. Et al. 2013. J Physiol. 591(Pt21): 5377-91. PMID 24018950. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/wnk4-mouse-antibody |
| 标 记 物 ： |
|
|
产品说明 ： |
|
