| 克隆类型 ： |
Mouse Monoclonal Antibody |
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亚 型 ： |
Mouse IgG1 |
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产品描述 ： |
The CD11a (HI111) antibody recognizes the 180-kDa integrin α chain associated with CD18, the 95-kDa integrin β2, which form a heterodimer glycoprotein called the lymphocyte function antigen-1 (LFA-1, CD11a/CD18). Leukocytes express four CD11/CD18 integrins which include a common β2 subunit and distinctive α chains. Besides CD11a/CD18, the other three integrins are known as CD11b/CD18, CD11c/CD18 and CD11d/CD18. LFA-1 is expressed on all leukocytes and is responsible for adhesion between leukocytes during immune response and transmigration of leukocytes across endothelium. The ligands for CD11a/CD18 are intercellular adhesion molecules CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). Patients bearing mutated CD18 genes do not express cell membrane LFA-1, a condition known as leukocyte adhesion deficiency 1 (LAD-1). |
| 适用物种 ： |
H |
|
应用范围 ： |
E, FC, IHC |
| 应用说明 ： |
Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections and antibody array. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
| 别 名 ： |
Integrin alpha-L; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11 antigen-like family member A; CD11a antigen; ITGAL; CD11A |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
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产品文献 ： |
[1] Revenfeld AL et al. 2016. J Circ Biomark. 5:3. [2] Jorgensen MM et al. 2015. J Extracell Vesicles. 4: 26048. PMID 25862471. [3] Knapp W., et al., eds. 1989. Leucocyte Typing IV: White Cell Differ |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/cd11a-hi111-antibody |
| 标 记 物 ： |
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产品说明 ： |
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