| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
mouse IgG2b |
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产品描述 ： |
The CD11b (HI11b) antibody recognizes the 165-kDa integrin αM-chain associated with CD18, the 95-kDa integrinβ2, which form a heterodimer glycoprotein called CD11b/CD18 (Mac-1). Leukocytes express four CD11/CD18 integrins which include a common β2 subunit and distinctive α chains. Besides CD11b/CD18, the other three integrins are known as CD11a/CD18, CD11c/CD18 and CD11d/CD18. Expression of the CD11b subunit on the leukocyte cell surface requires the presence of the CD18 subunit. Patients who have mutated CD18 genes do not express cell membrane Mac-1 (or the other β2 integrins), a condition known as leukocyte adhesion deficiency 1 (LAD-1), in which patients have major problems with bacterial infections. Mac-1 is highly expressed on neutrophils and monocytes/macrophages, a subset of NK cells, and activated lymphocytes. Mac-1 operates as a phagocytic receptor, has a role in myeloid cell transmigration and is also a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and fibrinogen. |
| 适用物种 ： |
H |
|
应用范围 ： |
E, FC, IHC |
| 应用说明 ： |
Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections and formalin-fixed paraffin tissues. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
| 别 名 ： |
Integrin alpha-M; Leukocyte adhesion receptor MO1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Neutrophil adherence receptor; CD11 antigen-like family member B; CD11b antigen; ITGAM; CD11B; CR3A |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
产品文献 ： |
[1] Zalfa C et al. 2016. Cell Death Dis. 7(8): e2311. PMID 27512952. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/cd11b-hi11b-antibody |
| 标 记 物 ： |
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产品说明 ： |
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