| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p70-S6K. |
|
产品描述 ： |
70 kDa ribosomal protein S6 kinase 1 (p70-S6K) acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. P70-S6K is a downstream effector of the mTOR signaling pathway. P70-S6K phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IP |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; S6K1; S6K; 70 kDa ribosomal protein S6 kinase1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha; RPS6KB1 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was immunoaffinity purified with c-terminal p70-S6K on agarose. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/p70-s6k-antibody |
| 标 记 物 ： |
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产品说明 ： |
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