| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Von Willebrand Factor. |
|
产品描述 ： |
Von Willebrand Factor (VWF) plays a role in the maintenance of hemostasis, where it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. It also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease (VWD), a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal, resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Vwf; vWF; von Willebrand factor; F8VWF; von Willebrand antigen 2; von Willebrand antigen II; VWF |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
产品文献 ： |
[1] Jiang Y. et al. 2015. Chongqing Medical University. 602:73-8. PMID#26149229 [2] Wu M. et al. 2014. Indian J Pharmacol. 46(2): 157-60. PMID# 24741185. [3] Wang X. et al. 2014. Stroke. 45(2): 619-62 |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/von-willebrand-factor-antibody |
| 标 记 物 ： |
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产品说明 ： |
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