| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated MAP synthetic peptide corresponding to human angiotensinogen II. |
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产品描述 ： |
Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Ang-II; Ang II; Angiotensin II; Angiotensin-2; AGT; Angiotensinogen; Serpin A8 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
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产品文献 ： |
[1] Zhang H et al. 2017. J Neuroimmunol. PMID 29169800. [2] Guo W et al. 2016. PLoS One. 11(4): e0153434. PMID 27073902. [3] Wang C. et al. 2015. J Cardiovasc Pharmacol. 66(3):285-293. PMID 25955575. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/angiotensin-ii-antibody |
| 标 记 物 ： |
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产品说明 ： |
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