| 克隆类型 ： |
Rabbit Polyclonal Antibody |
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亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within human NFKB p50. |
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产品描述 ： |
NF-kappa-B p50 subunit (NFKB p50) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, is subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. |
| 适用物种 ： |
H, M, R, D, P, B, Ck |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Nuclear factor NF-kappa-B p105/p50 subunit; DNA-binding factor KBF1; EBP-1; NFKB1; Nuclear factor NF-kappa-B p50 subunit; NFKB p105/p50 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
产品文献 ： |
Padiya R et al. 2014. PLoS One. 9(5): e94228. PMID# 24796753. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/nfkb-p50-antibody |
| 标 记 物 ： |
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产品说明 ： |
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