克隆类型 : |
Rabbit Polyclonal Antibody |
亚 型 : |
Rabbit Ig |
免 疫 原 : |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human STAT1. |
产品描述 : |
Signal transducer and activator of transcription 1-alpha/beta (STAT1) mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. STAT1 is tyrosine- and serine-phosphorylated in response to type II IFN (IFN-gamma). STAT1 deficiency results in impaired immune response leading to severe mycobacterial and viral diseases. In the case of complete deficiency, patients can die of viral disease. |
适用物种 : |
H, M, R |
应用范围 : |
E, WB, IHC |
应用说明 : |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
别 名 : |
Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1 |
形 态 : |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 50% glycerol with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
保存条件 : |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
产品链接 : |
http://www.abbiotec.com/antibodies/stat1-antibody |
标 记 物 : |
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产品说明 : |
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