| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Notch 1. |
|
产品描述 ： |
Neurogenic locus notch homolog protein 1 (Notch 1) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), Notch 1 forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 1 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in Notch 1 are a cause of bicuspid aortic valve (BAV), a common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, IHC |
| 应用说明 ： |
E: 1:1,000-1:10,000; IHC: 1:100-1:500 |
| 别 名 ： |
Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1; NOTCH1; TAN1 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/notch-1-antibody |
| 标 记 物 ： |
|
|
产品说明 ： |
|
|
