| 克隆类型 ： |
Rabbit Polyclonal Antibody |
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亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human AKR1C3. |
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产品描述 ： |
Aldo-keto reductase family 1 member C3 (AKR1C3) catalyzes the conversion of aldehydes and ketones to alcohols. AKR1C3 catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. AKR1C3 functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. AKR1C3 can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. AKR1C3 preferentially transforms androstenedione (4-dione) to testosterone. AKR1C3 is strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. AKR1C3 is also inhibited by the flavinoid rutin, and by selective serotonin inhibitors (SSRIs). |
| 适用物种 ： |
H |
|
应用范围 ： |
E, WB, IF, IHC |
| 应用说明 ： |
E: 1:10,000-1:30,000; WB: 1:100-1:1,000; IF: 1:50-1:200; IHC: 1:100-1:500 |
| 别 名 ： |
Aldo-keto reductase family 1 member C3; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Testosterone 17-beta-dehydrogenase 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; Prostaglandin F synthase; PGFS; Indanol dehydrogenase; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD-3; DD3; Chlordecone reductase homolog HAKRb; HA1753; AKR1C3; DDH1; HSD17B5; KIA0119; PGFS |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.02% sodium azide. Antibody was purified by antigen-affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/akr1c3-antibody |
| 标 记 物 ： |
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产品说明 ： |
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