| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TCF-4. |
|
产品描述 ： |
T-cell-specific transcription factor 4 (TCF-4) participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. TCF-4 acts as repressor in the absence of CTNNB1, and as activator in its presence. TCF-4 activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. Expression of dominant-negative TCF-4 mutants results in cell-cycle arrest in G1. Genetic variations in TCF-4 are associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:10,000-1:50,000; WB: 1:100-1:1,000; IHC: 1:50-1:250 |
| 别 名 ： |
Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4; TCF7L2; TCF4 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/tcf-4-antibody-0 |
| 标 记 物 ： |
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产品说明 ： |
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