| 克隆类型 ： |
Mouse Monoclonal Antibody, Phosphospecific Antibody |
|
亚 型 ： |
Mouse IgG |
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免 疫 原 ： |
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser294 of human progesterone receptor. |
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产品描述 ： |
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor. |
| 适用物种 ： |
M, R , H, Mk |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:1,000; IHC: 1:1,000; WB: 1:1,000 |
| 别 名 ： |
Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C4 |
|
形 态 ： |
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/progesterone-receptor-ser294-antibody |
| 标 记 物 ： |
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产品说明 ： |
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