| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of GATA3(aa175-388) expressed in E. coli. |
|
产品描述 ： |
GATA3 (GATA binding protein 3) is an enhancer-binding protein containing a zinc finger domain. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. A common TCR regulatory element was identified by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.
|
| 适用物种 ： |
H |
|
应用范围 ： |
WB |
| 应用说明 ： |
WB: 1:500-1:2000;
|
| 别 名 ： |
HDR; Trans-acting T-cell-specific transcription factor GATA-3 ; GATA-binding factor 3 |
|
形 态 ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/gata3-1a10-antibody |
| 标 记 物 ： |
|
|
产品说明 ： |
|
