| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human TUBB3 expressed in E. coli. |
|
产品描述 ： |
TUBB3 (Tubulin beta 3) is a highly conserved protein with a molecular weight of ~50 kD. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, α- and β-tubulin are usually products of separate genes. The β-tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III β-tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia and stem cell research. Class III β-tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy. |
| 适用物种 ： |
H |
|
应用范围 ： |
WB, IF, FC |
| 应用说明 ： |
WB: 1:500-1:2000;
IF: 1:200-1:1000;
FC: 1:200-1:400;
|
| 别 名 ： |
Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; TUBB4; TUBB3 |
|
形 态 ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/tubb3-2e9-antibody |
| 标 记 物 ： |
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产品说明 ： |
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