| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
Mouse IgG1 |
|
免 疫 原 ： |
Purified recombinant fragment of human CD276 expressed in E. coli. |
|
产品描述 ： |
CD276 is a member of Costimulatory B7 molecules, signal through CD28 family molecules such as CD28, CTLA4, and ICOS. It may participate in the regulation of T-cell-mediated immune response. It can be protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Also, may be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. CD276 could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| 适用物种 ： |
H |
|
应用范围 ： |
WB, IHC, IF |
| 应用说明 ： |
WB: 1:200-1:1000;
IHC: 1:200-1:1000;
IF: 1:200-1:1000;
|
| 别 名 ： |
CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3 Costimulatory molecule; CD276 PSEC0249; UNQ309/PRO352; B7H3; CD276 |
|
形 态 ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/cd276-6a1-antibody |
| 标 记 物 ： |
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产品说明 ： |
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