| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
Mouse IgG1 |
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免 疫 原 ： |
Synthesized peptide derived from internal of human POU5F1. |
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产品描述 ： |
Oct4 (Octamer-binding transcription factor-4) and Oct-3/4, also known as POU5F1 (POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues. |
| 适用物种 ： |
H |
|
应用范围 ： |
WB, IF |
| 应用说明 ： |
WB: 1:500-1:2000; IF: 1:200-1:1000; |
| 别 名 ： |
POU domain, class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3; OCT3; OCT4; OTF3; POU5F1 |
|
形 态 ： |
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件 ： |
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/oct4-7e7-antibody |
| 标 记 物 ： |
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产品说明 ： |
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