| 克隆类型 ： |
Rabbit Polyclonal Antibody |
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亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SIRP alpha. |
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产品描述 ： |
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, ICC |
| 应用说明 ： |
Cat. No. 253304 binds to SIRP alpha 1, 2 and 3. E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500 |
| 别 名 ： |
SIRP alpha ; SHPS-1; SIRPa; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha; p84; CD172a |
|
形 态 ： |
Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/sirp-alpha-antibody |
| 标 记 物 ： |
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产品说明 ： |
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