SOCS1 Antibody_华拓生物

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SOCS1 Antibody

产品名称 ： SOCS1 Antibody

中文名称 ：

产品类别 ：一抗

品　　牌 ： ABBIOTEC

货　　号 ： 253608

规　　格 ： 0.1mg

详细信息

克隆类型：	Rabbit Polyclonal Antibody
亚　　型：	Rabbit Ig
免疫原：	KLH-conjugated synthetic peptide encompassing a sequence within human SOCS1.
产品描述：	The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
适用物种：	H, M, R
应用范围：	E, WB
应用说明：	E: 1:500-1:1,000; WB: 1:100-1:500
别　　名：	SOCS1 ; Suppressor of cytokine signaling 1; JAK-binding protein; JAB
形　　态：	Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
保存条件：	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
产品链接：	http://www.abbiotec.com/antibodies/socs1-antibody
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产品说明：

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