SKA1 Antibody_华拓生物

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SKA1 Antibody

产品名称 ： SKA1 Antibody

中文名称 ：

产品类别 ：一抗

品　　牌 ： ABBIOTEC

货　　号 ： 254143

规　　格 ： 0.1mg

详细信息

克隆类型：	Rabbit Polyclonal Antibody
亚　　型：	Rabbit Ig
免疫原：	KLH-conjugated synthetic peptide encompassing a sequence within human SKA1.
产品描述：	Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.
适用物种：	H, M, R
应用范围：	E, WB
应用说明：	E: 1:500-1:1,000; WB: 1:100-1:500
别　　名：	SKA1; Spindle and kinetochore associated complex subunit 1
形　　态：	Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
保存条件：	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
产品链接：	http://www.abbiotec.com/antibodies/ska1-antibody
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