RNF8 Antibody_华拓生物

产品中心

抗体系列

RNF8 Antibody

产品名称 ： RNF8 Antibody

中文名称 ：

产品类别 ：一抗

品　　牌 ： ABBIOTEC

货　　号 ： 254286

规　　格 ： 0.1mg

详细信息

克隆类型：	Rabbit Polyclonal Antibody
亚　　型：	Rabbit Ig
免疫原：	KLH-conjugated synthetic peptide encompassing a sequence within human RNF8.
产品描述：	RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
适用物种：	H, M, R
应用范围：	E, WB, IF
应用说明：	E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:100-1:500
别　　名：	RNF8; Ring finger protein 8
形　　态：	Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
保存条件：	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
产品链接：	http://www.abbiotec.com/antibodies/rnf8-antibody
标记物：
产品说明：

{返回}

深圳公司
深圳市豪地华拓生物科技有限公司
地址：深圳市南山区南海大道海王大厦B座9H
微信： 13265824656
电话： 0755-26055215
邮箱： order@otwobiotech.com
Q Q ： 1245980541 971848080

广州公司
地址：广州市天河工业园建中路62号迪宝大厦五楼
电话： 020-85557146
邮箱： order@otwobiotech.com

武汉研发中心
地址：武汉市东湖技术开发区光谷生物城B1栋
电话： 027-87886579
邮箱： order@otwobiotech.com