| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PION. |
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产品描述 ： |
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta−amyloid protein precursor (APP) is cleaved by one of two beta−secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma−secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients’ brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IF, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; IHC: 1:100-1:500 |
| 别 名 ： |
Protein pigeon homolog; gamma-secretase activating protein; GSAP; PION |
|
形 态 ： |
Each vial contains 0.1 ml IgG at 1 mg/ml in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/pion-antibody |
| 标 记 物 ： |
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产品说明 ： |
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