| 克隆类型 ： |
Rabbit Polyclonal IgG |
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免 疫 原 ： |
Peptide derived from Hu ROR1/ROR alpha corresponding to amino acids. |
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纯化方式 ： |
Immunogen affinity purified |
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缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
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产品描述 ： |
NR1F1; Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. These isotypes have been shown to differ in only their amino terminus, and their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The structure of the ligand binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth and differentiation. |
| 适用物种 ： |
Hu, Mo, Rat, Dog, Pig, Cow, Hor |
| 应用说明 ： |
WB: 1:200-1:1000 E: 1:500-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
NR1F1; Nuclear receptor ROR alpha; Nuclear receptor RZR alpha; RAR related orphan receptor A; RAR related orphan receptor alpha; ROR 1; ROR 2; ROR 3; ROR A; ROR1; ROR2. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
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产品说明 ： |
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