|
序 列 ： |
Human: H-Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2 or H-VPNLPQRF-NH2 |
| 分 子 式 ： |
C45H72N14O10 |
|
分 子 量 ： |
969.1 g/mol |
|
纯 度 ： |
Purity > 95% by HPLC |
|
形 态 ： |
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt. |
|
溶 解： |
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
|
保存条件 ： |
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C. |
| 产品链接 ： |
http://www.abbiotec.com/peptides/rfrp-3-peptide |
|
产品说明 ： |
|
| 产品描述 ： |
RFamide-related peptides (RFRP-1 and RFRP-3) belong to a group of RFamide peptides, which have an arginine-phenylalanine-amide structure at the C-term end. RFRPs share a similar C-term sequence with neuropeptide FF (NPFF) and have a relatively high affinity to GPR147 (also called NPFF1 receptor, RFRP receptor or OT7T022). RFRP-1 facilitates prolactin release from the pituitary and attenuates morphine-induced analgesia. RFRP-3 inhibits the gonadotrophin-releasing hormone neuron-luteinising hormone system in mammals and increases food intake. RFRP-1 and RFRP-3 are derived from the same preprotein (Pro-FMRFamide-related neuropeptide VF) and are co-expressed in single neurons in the dorsomedial hypothalamus, which plays a pivotal role in the control of stress responses in neuroendocrine, autonomic and behavioral systems. RFRP-3 inhibits forskolin-stimulated cAMP production in CHO cells expressing OT7T022 (ED50=0.7 nM). |
