产品货号Reference:             CAN-TE-6090
检测方法Kit Type:                Competitive LIA
规格Kit Size:                        96-well break-apart microplate
灵敏度Sensitivity:                1 pg/mL
检测样本Sample Type:         Human saliva / 100 μL
校准范围Calibrator Range:  2–800 pg/mL
检测时间Total Assay Time:  120 minutes
背景介绍：
睾酮是一种C-19类固醇，男性是从睾丸和肾上腺皮质分泌的，女性是从肾上腺皮质和卵巢分泌的。睾酮也是由雄烯二酮的外周组织产生的，这在男性中没有什么生理意义，但在女性中，大约有一半的循环睾酮是从这个来源产生的。睾酮的作用既有雄激素的作用，也有合成代谢的作用。睾酮测量主要用于男性性腺功能减退和女性高雄激素状态的临床评估。
大多数循环睾酮与三种蛋白质结合：性激素结合球蛋白(44-78%)、白蛋白(20-54%)和皮质醇结合球蛋白(少量)。只有大约2-3%的总循环睾酮仍然没有束缚或以自由的形式。只有循环睾酮的游离部分(或非SHBG结合部分)被认为可用于发挥其生物学作用的组织。
唾液激素测定法因其无创、简便的标本采集方法而备受推崇。唾液睾酮具有很高的临床价值，因为它代表血浆睾酮的百分比。许多研究表明唾液睾酮与游离或非SHBG结合的睾酮有很好的相关性。
Testosterone is a C-19 steroid secreted from the testis and the adrenal cortex in men and from the adrenal cortex and ovary in women. Testosterone is also produced by peripheral tissues from androstenedione, which is of little physiological signifi cance in men, however in women about half of circulating testosterone is derived from this origin. The action of testosterone is both androgenic and anabolic. Testosterone measurements are used mainly for clinical evaluation of hypogonadism in males and hyperandrogenic states in females.
Most of the circulating testosterone is bound to three proteins: sex hormone binding globulin (44–78%), albumin (20–54%) and cortisol binding globulin (small amount). Only about 2–3%of the total circulating testosterone remains unbound or in the free form. Only the free portion (or the non-SHBG bound fraction) of the circulating testosterone is thought to be available to tissues where it exerts its biological actions.
The salivary hormone assays are advocated for their non-invasive, easy sample collection method. Salivary testosterone is of great clinical value for it represents a fi ltered fraction of plasma testosterone and is independent of flow rate. Many studies have suggested that salivary testosterone correlates well with either free or non-SHBG bound testosterone.

注：本产品仅用于科研用途，不能直接用于人体或临床诊断使用。