产品货号Reference:                CAN-P-400
检测方法Kit Type:                  Competitive ELISA
规格Kit Size:                          96-well break-apart microplate
灵敏度Sensitivity:                  0.051 ng/mL
检测样本Sample Type:          Human serum / 25 μL
检测范围Calibrator Range:   0.15–20 ng/mL
检测时间Total Assay Time:   80 minutes

背景介绍：

类固醇17α-羟孕酮是由肾上腺皮质和性腺产生的。17-α-OHP几乎没有孕激素活性，它是11-脱氧皮质醇(CPD-S)的直接前体，CPD-S是由17个α-OHP的21-羟基化反应生成的。17-α-OHP的测定是检测21-羟化酶活性的一个有用的间接指标。在先天性肾上腺皮质增生症最常见的21-羟化酶脱氢酶中，17-羟化酶(17-fi-α)分泌过多。因此，检测17例α-OHP对CAH的早期诊断有重要价值。
The steroid 17α-hydroxyprogesterone is produced by the adrenal cortex and gonads. 17α-OHP has little progestational activity, but it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Cpd-S is produced by the 21-hydroxylation of 17α-OHP. Measurement of 17α-OHP is a useful indirect indicator of 21-hydroxlase activity. In congenital 21-hydroxylase defi ciency, the most common variety of congenital adrenal hyperplasia (CAH), 17α-OHP is secreted in abundant excess. Measurement of 17α-OHP is therefore valuable in the initial diagnosis of CAH.