膜联蛋白A1(AnnexinA1，ANXA1)是一种膜蛋白，通过控制炎症、前列腺素和白三烯介质的生物合成，在先天免疫和适应性免疫中发挥作用。在毛细胞白血病患者的所有样本中，97%的样本中该靶蛋白过表达，而在其他B细胞淋巴瘤中未见该靶蛋白的表达。ANXA1高表达常与晚期食管和食管胃交界区腺癌有关，也与晚期和转移性疾病有关。

Annexin A1 (ANXA1) is a membrane protein that plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandins, and leukotriene mediators. This target is overexpressed in 97% of all samples from patients with with hairy cell leukemia, and is absent in other B-cell lymphomas. High ANXA1 expression is frequently associated with advanced stage esophageal and esophagogastric junction adenocarcinoma, and is also linked to advanced and metastatic disease states.

 

 

Clone                 IHC512

Source                 Mouse Monoclonal

Positive Control Hairy Cell Leukemia

Dilution Range 1:50-1:200

 

1. Tiacci E, et al. N Eng J Med. 2011; 364:2305-2315.

2. Wang K, et al. Clin Cancer Res. 2006; 12:4598-4604.