精氨酸酶-1(Arginase-1，Arginase-1)是由ARG1基因编码的一种胞浆金属酶，主要在肝细胞中表达，催化精氨酸水解为鸟氨酸和尿素，在尿素循环中起关键作用。精氨酸血症是一种遗传的常染色体隐性遗传病，其特点是血液中精氨酸和氨的积累。抗精氨酸酶-1对肝细胞具有很高的特异性，是一种敏感、特异的良、恶性肝肿瘤标志物。

Arginase-1, encoded by the ARG1 gene, is a cytosolic metalloenzyme expressed predominantly in hepatocytes which plays a key role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Argininemia is an inherited autosomal recessive disorder characterized by a buildup of arginine and ammonia in the blood. Anti-Arginase-1 is highly specific for hepatocytes, and is therefore a sensitive and specific marker of benign and malignant hepatic tumors.

 

Clone                   IHC400

Source                 Mouse Monoclonal

Positive Control Liver

Dilution Range 1:50-1:200

 

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3. Yan BC, et al. Am J Surg Pathol. 2010; 34:1147-1154.