背景描述Description：

ClusterofDifferentiation57，CD57又称NK-1，是一种可在自然杀伤细胞、部分T淋巴细胞和正常外周血单个核细胞、髓系细胞以及多种多肽、脂类和硫酸软骨素蛋白多糖中检测到的抗原。CD57是一种神经内分泌来源的肿瘤标志物，包括嗜铬细胞瘤、副神经节瘤、类癌和髓母细胞瘤，以及各种神经肿瘤，包括神经瘤、神经纤维瘤、神经鞘瘤和颗粒细胞瘤。CD57在神经节细胞瘤和前列腺癌中也有表达。抗CD57抗体用于鉴别结节性淋巴细胞性霍奇金淋巴瘤与T细胞/组织细胞丰富的大B细胞淋巴瘤、结节性硬化型霍奇金病和滤泡性淋巴瘤。

Cluster of differentiation 57 (CD57), also known as NK-1, is an antigen detectable in natural killer cells, some T-lymphocytes and normal peripheral blood mononuclear cells, myeloid cells, and a variety of polypeptides, lipids, and chondroitin sulfate proteoglycans. CD57 is indicated as a marker for tumors of neuroendocrine origin, including pheochromocytomas, paragangliomas, carcinoid tumor, and medulloblastomas, as well as various neural tumors including neuromas, neurofibromas, schwannomas, and granular cell tumors. CD57 is also detectable in ganglioneuroma and prostate carcinoma. Anti-CD57 is used to distinguish nodular lymphocyte-predominant Hodgkin’s lymphoma from T-cell/histiocyte-rich large B-cell lymphoma, nodular sclerosis Hodgkin’s disease, and follicular lymphoma.

Specifications：

Clone                    IHC539

Source                 Mouse Monoclonal

Positive Control Tonsil

Dilution Range 1:50-1:200

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