Ⅳ型胶原是基底膜的主要成分，可作为观察基底膜是否存在和检查其结构的标志。除上皮基底层外，抗Ⅳ型胶原染色间充质成分。它有助于鉴别软组织肿瘤，包括神经鞘瘤和平滑肌瘤。抗Ⅳ型胶原抗体在分化良好、恶性后常与这些组织发生反应。在研究肿瘤的血管成分、血管外皮细胞瘤、血管肉瘤和上皮样血管内皮瘤时，抗Ⅳ型胶原蛋白的应用比非特异性的银网状染色法产生更可靠的结果。

Collagen Type IV is a primary component in the basal lamina that is used as a marker to observe the presence of the lamina and examine its structure. In addition to the epithelial basal lamina, Anti-Collagen Type IV stains mesenchymal components. It is useful for identifying soft tissue cancers including schwannomas and leiomyomas. Anti-Collagen Type IV frequently reacts with these tissues after becoming well-differentiated and malignant. The use of Anti-Collagen Type IV produces more reliable results than non-specific silver reticulum stains when investigating the vascular elements of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma.

 

Clone IHC549

Source Mouse Monoclonal

Positive Control Lung,  Muscle

Dilution Range 1:50-1:200

 

Gould VE, et al. Pathol Annul. 1976; 11:353-86.

McArdle JP, et al. Int J Cancer. 1984: 34:633-8.

Sakr WA, et al. Hum Pathol. 1987; 18:1043-50.

Barsky SH, et al. Am J Surg Pathol. 1983; 7:667-77.

De Iorio P, et al. Anticancer Res. 2001; 21:1395-9.

Maatta M, et al. J Histochem Cytochem. 2001; 49:711-26.

Schmehl K, et al. Int J Colorectal Dis. 2000; 15:39-48.

Felix A, et al. Hum Pathol. 1999; 30:964-9.

Damiani S, et al. Virchows Arch. 1999; 434:227-34.