细胞角蛋白19(CK19)在上皮组织胞浆内的细胞骨架中形成中间丝，并提供机械支持。抗细胞角蛋白19染色上皮和上皮恶性肿瘤，如结肠癌，胃癌，胰腺癌，胆道癌，肝癌和乳腺癌。细胞角蛋白19是区分肝细胞癌和肝内胆管细胞癌的有用指标。细胞角蛋白7、CAM5.21、Ber-Ep4/MOC31、HepPar1和TTF1联合染色可促进这种分化。细胞角蛋白19染色也可用于甲状腺乳头状癌的鉴别。

Cytokeratin 19 (CK19) forms intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue and provides mechanical support. Anti-Cytokeratin 19 stains epithelia and epithelial malignancies such as carcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Cytokeratin 19 is a useful marker for distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinoma. This differentiation is improved when stained in combination with Cytokeratin 7, CAM5.2l, Ber-EP4/MOC31, HepPar1 and TTF1. Cytokeratin 19 staining can also be used to recognize thyroid papillary carcinomas.

 

Clone IHC019

Source Mouse Monoclonal

Positive Control Bladder, Colon Carcinoma, Colon, Thyroid Carcinoma

Dilution Range 1:50-1:200

 

Jain R, et al. Appl Immunohistochem Mol Morphol. 2010; 18:9-15.

Rosai J. Tumori. 2003; 89:517-9.

de Matos LL, et al. Diagn Pathol. 2012; 7:97.