Ki-67是一种核内非组蛋白，仅在细胞周期的活跃期(G1、S、G2和M期)表达，而在静止期(G0和G1早期)不表达。虽然该抗原也与核糖体RNA转录相关，但它与细胞增殖密切相关，因此被认为是对包括大脑、乳腺、宫颈和前列腺在内的肿瘤的增殖率进行分级的有效标记物。

Ki-67 is a nuclear, non-histone protein that is expressed only during active phases of the cell cycle (G1, S, G2 and M), but not in the resting phases (G0 and G1 early phase). Although the antigen has also been associated with ribosomal RNA transcription, it is strongly linked to cell proliferation and has thus been indicated as an effective marker in grading the proliferation rate of tumors, including those of the brain, breast, cervix, and prostate.

 

Clone IHC067

Source Mouse Monoclonal

Positive Control Tonsil

Dilution Range 1:50-1:200

 

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