神经生长因子受体(NerveGrowthFactor Receptor，NGFR)又称p75、P-75NTR或CD271，是肿瘤坏死因子受体家族中的一种神经营养因子受体。NGFR主要表达于雪旺细胞和神经元，以及其他一些非神经细胞类型，在中枢和周围神经系统发育过程中发挥调节神经元生长、迁移、分化和细胞死亡的作用。神经生长因子受体也在黑素细胞、黑色素瘤、神经母细胞瘤、嗜铬细胞瘤、神经纤维瘤、神经化痣(C型黑素细胞)及其他神经嵴细胞或肿瘤衍生物中表达。NGFR可能是前列腺癌和尿路上皮癌的肿瘤抑制因子，抗神经生长因子受体(anti-nervegrowthfactorreceptor，NGFR)常与S100结合使用，以辅助诊断促结缔组织增生性和神经营养性恶性黑色素瘤。抗NGFR抗体标记乳腺导管肌上皮细胞和乳腺导管小叶内成纤维细胞，有助于乳腺癌的诊断。

Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and neurons, as well as a number of other non-neuronal cell types, and functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed in melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives. It has been suggested that NGFR may act as a tumor suppressor indicated in prostate and urothelial cancer, and Anti-Nerve Growth Factor Receptor (NGFR) is often used in adjunct with S100, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas. Anti-NGFR is also useful as an aid in the diagnosis of breast malignancy, as the antibody labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts.

 

Clone IHC637

Source Mouse Monoclonal

Positive Control Breast

Dilution Range 1:50-1:200

 

Radfar A, et al. Am J Dermatopathol. 2006; 28:162-7.

Kaplan DR, et al. Curr Opin Cell Biol. 1997; 9:213-21.

Bunone G, et al. Oncogene. 1997; 14:1463-70.

Kanik AB, et al. J Cutan Pathol. 1996; 23:205-10.

Laskin WB, et al. Hum Pathol. 2000; 31:1230-41.

Lewis Kelso R, et al. Dermatol Surg. 2006; 32:177-83.

Liang Y, et al. J Invest Dermatol. 1998; 111:114-8.

Liang Y, et al. J Cutan Pathol. 1998; 25:189-98.