p53又称肿瘤蛋白53(TumorProtein53，TP53)，是一种肿瘤抑制因子和转录因子，在DNA损伤或其他应激源引起的细胞凋亡、DNA修复、细胞周期阻滞等多种抗癌活动中发挥重要作用。p53的突变与许多恶性肿瘤有关，包括乳腺、卵巢、膀胱、结肠、肺和黑色素瘤。抗p53染色已用于检测肾小管内生殖细胞肿瘤，并用于区分子宫浆液性癌和子宫内膜样癌。

p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.

 

Clone IHC053

Source Mouse Monoclonal

Positive Control Colon Carcinoma

Dilution Range 1:50-1:200

 

Stoehlmacker J, et al. Oncol. 2003; 30:10-16.

Gallo O, et al. Hum Pathol. 2002; 33:708-714.

Sano H, et al. Cancer Res. 1995: 55:3785-9.

Denkert C, et al. Cancer. 2003; 97:2978-87.

Sheehan KM, et al. Hum Pathol. 2003; 34:1242-1246.

Moore BE, et al. Appl Immunohistochem Mol Morphol. 2001; 9:203-6.

Mauri FA, et al. Int J Oncol. 1999; 15:1137-47.

Caffo O, et al. Clin Cancer Res. 1996; 2:1591-9.

Bebenek M, et al. Anticancer Res. 1998; 18:619-23.

Midulla C, et al. Anticancer Res. 1999; 19:4033-7.

Zen ZS, et al. J Clin Oncol. 1994; 12:2043-50.

Quinlan DC, et al. Cancer Res. 1992; 53:4828-31.

Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.

Liang Y, et al. Arch Dermatol Res. 1999; 291:14-21.